This region is characterized for having a massif plain that extends from the Colombian Andean Mountain range, and surrounds the Sierra Nevada de Santa Marta mountain range (which is not part of the Andes) and covers the Guajira Peninsula to border the Caribbean sea. In the western side of the region there is also a relative low altitude mountain range, the Montes de Maria which are also separate from the Andean mountain range.
The Caribbean region is crossed by many rivers and contains one of the largest marshes in Colombia, the Ciénaga Grande de Santa Marta marsh among many others. The main river is the Magdalena which is fully navigable in the region and a major path for the flow of shipments to and from inland Colombia. The Madgalena river has numerous sub basins within its basin.